miklechen123
New Member
What is resveratrol:
Resveratrol (trans-3,5,4'-trihydroxystilbene), belongs to a class of polyphenolic compounds called stilbenes , found largely in the skins of red grapes and root of Polygonum cuspidatum Sieb. et Zucc ( Japanese knotweed), is a component of Ko-jo-kon, an oriental medicine used to treat diseases of the blood vessels, heart and live.. Resveratrol is a fat-soluble compound that occurs in a trans and a cis configuration (see figure 1). Both cis- and trans-resveratrol also occur as glucosides (bound to a glucose molecule). Resveratrol-3-O-beta-glucoside is also called piceid.
Cardiovascular Effects
Many studies suggest that consuming alcohol (especially red wine) may reduce the incidence of coronary heart disease (CHD). Several studies have demonstrated that resveratrol is an effective antioxidant. It inhibits lipid peroxidation of low-density lipoprotein (LDL), prevents the cytotoxicity of oxidized LDL, and protects cells against lipid peroxidation. It is thought that because it contains highly hydrophilic and lipophilic properties, it can provide more effective protection than other well-known antioxidants, such as vitamins C and E. On the other hand, it is less effective than the antioxidants quercetin and epicatechin found in red wine. Reduced platelet aggregation has also been demonstrated in studies on resveratrol, further contributing to its prevention of atherosclerosis. To date, most of the research on resveratrol's antioxidant and anti-platelet properties has been done in vitro (in an artificial environment using test-tube or tissue-culture preparations). Further studies in animals and humans are necessary to determine whether resveratrol supplementation makes sense.
Cancer-Related Effects
Resveratrol is being studied to see how it affects the initiation, promotion, and progression of cancer. With regard to tumor initiation, it has been shown to act as an antioxidant by inhibiting free radical formation, and as an anti-mutagen in rat models. Resveratrol appears to decrease tumor promotion activity by inhibiting cyclooxygenase-1 (COX-1), an enzyme that converts arachidonic acid to pro-inflammatory substances that stimulate tumor-cell growth . Studies related to progression have found that resveratrol induced human promyelocytic leukemia cell differentiation and inhibited ribonucleotide reductase, an enzyme needed for DNA synthesis in proliferating cells . One appealing characteristic of resveratrol's anti-cancer potential is its minimal toxicity to blood-forming cells . More studies using both cellular and animal models are needed before any such data would be applicable to human use.
The similarity in structure between resveratrol and diethylstilbestrol (a synthetic estrogen) has prompted investigations into resveratrol's potential as a phytoestrogen (a plant compound that produces estrogen-like effects). However, these properties also stimulate the growth of human breast cancer cells . This finding seems contrary to its other anticancer activities, and is a cause for concern.
The Natural Products Association was cited in an article regarding a new dietary supplement that contains resveratrol, a substance researchers believe may help protect human cells from diseases such as cancer and arthritis.
Direct Antioxidant Activity
In the test tube, resveratrol effectively scavenges (neutralizes) free radicals and other oxidants and inhibits low density lipoprotein (LDL) oxidation . However, there is little evidence that resveratrol is an important antioxidant in vivo . After oral consumption of resveratrol, circulating and intracellular levels of resveratrol in humans are likely to be much lower than that of other important antioxidants, such as vitamin C, vitamin E and glutathione. Moreover, the antioxidant activity of resveratrol metabolites, which comprise most of the circulating resveratrol, may be lower than that of resveratrol.
Inhibition of Vascular Smooth Muscle Cell Proliferation
The proliferation of vascular smooth muscle cells plays an important role in the progression of atherosclerosis . Resveratrol has been found to inhibit the proliferation of vascular smooth muscle cells in culture .
Inhibition of Platelet Aggregation
Platelet aggregation is one of the first steps in the formation of a blood clot that can occlude a coronary or cerebral artery, resulting in myocardial infarction or stroke. Resveratrol has been found to inhibit platelet aggregation in vitro.
Safety & Adverse Effects
Resveratrol is not known to be toxic or cause adverse effects in humans, but there have been few controlled clinical trials. In rats, daily oral administration of trans-resveratrol at doses up to 300 mg/kg of body weight for 4 weeks resulted in no apparent adverse effects .
Pregnancy and Lactation
The safety of resveratrol-containing supplements during pregnancy and lactation has not been established. Since no safe level of alcohol consumption has been established at any stage of pregnancy, pregnant women should avoid consuming wine as a source of resveratrol.
Estrogen-sensitive Cancers
Until more is known about the estrogenic activity of resveratrol in humans, women with a history of estrogen-sensitive cancers, such as breast, ovarian and uterine cancers, should avoid resveratrol supplements (see Estrogenic and Anti-estrogenic Activities above).
Drug Interactions Anticoagulant and Antiplatelet Drugs
Resveratrol has been found to inhibit human platelet aggregation in vitro (42, 84). Theoretically, high intakes of resveratrol (e.g., from supplements) could increase the risk of bleeding when taken with anticoagulant drugs, such as warfarin (Coumadin), and antiplatelet drugs, such as clopidogrel (Plavix), dipyridamole (Persantine), non-steroidal anti-inflamatory drugs (NSAIDs), aspirin and others.
Do you suffer diarrhea after taken resveratrol?
There are many consumers suffer diarrhea after taking Resvertrol.
Resveratrol is a strong antioxidant ingredient and has been proved to be very useful to prolong life, and it is very safe. Currently, Resvertrol is very popular.
Lots of consumers purchase Resvertrol from healthy supplement store or net-shop. However, Resveratrol market has met a difficulty recently due to many consumers claim that they were suffered from diarrhea. It is very difficult for the consumers to accept a product which may bring them to diarrhea problem even if the product can bring lots of benefits to their health.
So why there are so many consumers suffer from diarrhea?
Resveratrol is very safe and will not bring any uncomfortable to human body. The reason why consumers suffer from diarrhea is they take an unpurified resvaratrol from Japanese knotweed (Polygonum cuspidatum Sieb also called Hu Zhang). Japanese knotweed has an ingredient called Emodin.
Emodin is a component which will bring you into diarrhea trouble. Normally, there are 5% to 7% Emodin content in 50% resveratrol product which is extracted from Japanese knotweed. There are some factories who can reduce Emodin to be only 1% content or less.
Who can reduce the Emodin? Who can reduce a risk of diarrhea problem? No matter how high or how less the emodin is, you will meet the diarrhea problem as long as emodin is still present. Not everyone will meet a diarrhea problem even he receives a content of emodin into their body since different people have different sensitivity to emodin. The best way to avoid diarrhea problem is to choose non emodin resveratrol product or a resveratrol which is extract from Grape Skin. There is no emodin present in raw grape skin. So, you don’t need to worry about diarrhea problem, just enjoy the benefits resveratrol.
If you are planning to take resveratrol, please don’t forget to ask your physician's advice. Remember to ask the content of emodin in your resveratrol product.
Product Specification :50%, 98%, 99% Resveratrol
Latin Name
olygonum Cuspidatum
Product Type: Powdered Extract
Part of the Plant Used Root & Rhizome
Extract Method: Grain Alcohol
Our Resveratrol is extracted from Polygonium cuspidatum and grape skin, its rich with Both cis- resveratrol and trans-resveratrol
If you have interests about our products, please send E-mail or call me and other ways to contact me as soon as possible .
Contact : Mr. Chen
Please contact....
Resveratrol (trans-3,5,4'-trihydroxystilbene), belongs to a class of polyphenolic compounds called stilbenes , found largely in the skins of red grapes and root of Polygonum cuspidatum Sieb. et Zucc ( Japanese knotweed), is a component of Ko-jo-kon, an oriental medicine used to treat diseases of the blood vessels, heart and live.. Resveratrol is a fat-soluble compound that occurs in a trans and a cis configuration (see figure 1). Both cis- and trans-resveratrol also occur as glucosides (bound to a glucose molecule). Resveratrol-3-O-beta-glucoside is also called piceid.
Cardiovascular Effects
Many studies suggest that consuming alcohol (especially red wine) may reduce the incidence of coronary heart disease (CHD). Several studies have demonstrated that resveratrol is an effective antioxidant. It inhibits lipid peroxidation of low-density lipoprotein (LDL), prevents the cytotoxicity of oxidized LDL, and protects cells against lipid peroxidation. It is thought that because it contains highly hydrophilic and lipophilic properties, it can provide more effective protection than other well-known antioxidants, such as vitamins C and E. On the other hand, it is less effective than the antioxidants quercetin and epicatechin found in red wine. Reduced platelet aggregation has also been demonstrated in studies on resveratrol, further contributing to its prevention of atherosclerosis. To date, most of the research on resveratrol's antioxidant and anti-platelet properties has been done in vitro (in an artificial environment using test-tube or tissue-culture preparations). Further studies in animals and humans are necessary to determine whether resveratrol supplementation makes sense.
Cancer-Related Effects
Resveratrol is being studied to see how it affects the initiation, promotion, and progression of cancer. With regard to tumor initiation, it has been shown to act as an antioxidant by inhibiting free radical formation, and as an anti-mutagen in rat models. Resveratrol appears to decrease tumor promotion activity by inhibiting cyclooxygenase-1 (COX-1), an enzyme that converts arachidonic acid to pro-inflammatory substances that stimulate tumor-cell growth . Studies related to progression have found that resveratrol induced human promyelocytic leukemia cell differentiation and inhibited ribonucleotide reductase, an enzyme needed for DNA synthesis in proliferating cells . One appealing characteristic of resveratrol's anti-cancer potential is its minimal toxicity to blood-forming cells . More studies using both cellular and animal models are needed before any such data would be applicable to human use.
The similarity in structure between resveratrol and diethylstilbestrol (a synthetic estrogen) has prompted investigations into resveratrol's potential as a phytoestrogen (a plant compound that produces estrogen-like effects). However, these properties also stimulate the growth of human breast cancer cells . This finding seems contrary to its other anticancer activities, and is a cause for concern.
The Natural Products Association was cited in an article regarding a new dietary supplement that contains resveratrol, a substance researchers believe may help protect human cells from diseases such as cancer and arthritis.
Direct Antioxidant Activity
In the test tube, resveratrol effectively scavenges (neutralizes) free radicals and other oxidants and inhibits low density lipoprotein (LDL) oxidation . However, there is little evidence that resveratrol is an important antioxidant in vivo . After oral consumption of resveratrol, circulating and intracellular levels of resveratrol in humans are likely to be much lower than that of other important antioxidants, such as vitamin C, vitamin E and glutathione. Moreover, the antioxidant activity of resveratrol metabolites, which comprise most of the circulating resveratrol, may be lower than that of resveratrol.
Inhibition of Vascular Smooth Muscle Cell Proliferation
The proliferation of vascular smooth muscle cells plays an important role in the progression of atherosclerosis . Resveratrol has been found to inhibit the proliferation of vascular smooth muscle cells in culture .
Inhibition of Platelet Aggregation
Platelet aggregation is one of the first steps in the formation of a blood clot that can occlude a coronary or cerebral artery, resulting in myocardial infarction or stroke. Resveratrol has been found to inhibit platelet aggregation in vitro.
Safety & Adverse Effects
Resveratrol is not known to be toxic or cause adverse effects in humans, but there have been few controlled clinical trials. In rats, daily oral administration of trans-resveratrol at doses up to 300 mg/kg of body weight for 4 weeks resulted in no apparent adverse effects .
Pregnancy and Lactation
The safety of resveratrol-containing supplements during pregnancy and lactation has not been established. Since no safe level of alcohol consumption has been established at any stage of pregnancy, pregnant women should avoid consuming wine as a source of resveratrol.
Estrogen-sensitive Cancers
Until more is known about the estrogenic activity of resveratrol in humans, women with a history of estrogen-sensitive cancers, such as breast, ovarian and uterine cancers, should avoid resveratrol supplements (see Estrogenic and Anti-estrogenic Activities above).
Drug Interactions Anticoagulant and Antiplatelet Drugs
Resveratrol has been found to inhibit human platelet aggregation in vitro (42, 84). Theoretically, high intakes of resveratrol (e.g., from supplements) could increase the risk of bleeding when taken with anticoagulant drugs, such as warfarin (Coumadin), and antiplatelet drugs, such as clopidogrel (Plavix), dipyridamole (Persantine), non-steroidal anti-inflamatory drugs (NSAIDs), aspirin and others.
Do you suffer diarrhea after taken resveratrol?
There are many consumers suffer diarrhea after taking Resvertrol.
Resveratrol is a strong antioxidant ingredient and has been proved to be very useful to prolong life, and it is very safe. Currently, Resvertrol is very popular.
Lots of consumers purchase Resvertrol from healthy supplement store or net-shop. However, Resveratrol market has met a difficulty recently due to many consumers claim that they were suffered from diarrhea. It is very difficult for the consumers to accept a product which may bring them to diarrhea problem even if the product can bring lots of benefits to their health.
So why there are so many consumers suffer from diarrhea?
Resveratrol is very safe and will not bring any uncomfortable to human body. The reason why consumers suffer from diarrhea is they take an unpurified resvaratrol from Japanese knotweed (Polygonum cuspidatum Sieb also called Hu Zhang). Japanese knotweed has an ingredient called Emodin.
Emodin is a component which will bring you into diarrhea trouble. Normally, there are 5% to 7% Emodin content in 50% resveratrol product which is extracted from Japanese knotweed. There are some factories who can reduce Emodin to be only 1% content or less.
Who can reduce the Emodin? Who can reduce a risk of diarrhea problem? No matter how high or how less the emodin is, you will meet the diarrhea problem as long as emodin is still present. Not everyone will meet a diarrhea problem even he receives a content of emodin into their body since different people have different sensitivity to emodin. The best way to avoid diarrhea problem is to choose non emodin resveratrol product or a resveratrol which is extract from Grape Skin. There is no emodin present in raw grape skin. So, you don’t need to worry about diarrhea problem, just enjoy the benefits resveratrol.
If you are planning to take resveratrol, please don’t forget to ask your physician's advice. Remember to ask the content of emodin in your resveratrol product.
Product Specification :50%, 98%, 99% Resveratrol
Latin Name
olygonum CuspidatumProduct Type: Powdered Extract
Part of the Plant Used Root & Rhizome
Extract Method: Grain Alcohol
Our Resveratrol is extracted from Polygonium cuspidatum and grape skin, its rich with Both cis- resveratrol and trans-resveratrol
If you have interests about our products, please send E-mail or call me and other ways to contact me as soon as possible .
Contact : Mr. Chen
Please contact....
Last edited by a moderator: