Dear Member,
NEEM IS SACRED & MEDICINAL TREE OF INDIA.
Neem leaf or bark is considered an effective pitta pacifier due to its bitter taste. Hence, it is traditionally recommended during early summer in Ayurveda (that is, the month of Chaitra as per the Hindu Calendar which usually falls in the month of March - April), and during Gudi Padva, which is the New Year in the state of Maharashtra, the ancient practice of drinking a small quantity of neem juice or paste on that day, before starting festivities, is found. As in many Hindu festivals and their association with some food to avoid negative side-effects of the season or change of seasons, neem juice is associated with Gudi Padva to remind people to use it during that particular month or season to pacify summer pitta. In Tamilnadu during the summer months of April to June, the Mariamman temple festival is a thousand year old tradition. The Neem leaves and flowers are the most important part of the Mariamman festival. The goddess Mariamman statue will be garlanded with Neem leaves and flowers. During most occasions of celebrations and weddings the people of Tamilnadu adorn their surroundings with the Neem leaves and flowers as a form of decoration and also to ward off evil spirits and infections.
In the eastern coastal state of Orissa the famous Jagannath temple idols are made up of Neem heart wood along with some other essential oils and powders.
AZADIRACHTIN
A chemical compound belonging to the limonoid group, is a secondary metabolite present in neem seeds. It was initially found to be active as a feeding inhibitor towards the desert locust (Schistocerca gregaria),[2] it is now known to affect over 200 species of insect, by acting mainly as an antifeedant and growth disruptor, and as such it possesses considerable toxicity toward insects (LD50(S. littoralis): 15 μg/g). It fulfills many of the criteria needed for a natural insecticide if it is to replace synthetic compounds. Azadirachtin is biodegradable (it degrades within 100 hours when exposed to light and water) and shows very low toxicity to mammals (the LD50 in rats is > 3,540 mg/kg making it practically non-toxic).
This compound is found in the seeds (0.2 to 0.8 percent by weight) of the neem tree, Azadirachta indica (hence the prefix aza does not imply an aza compound, but refers to the scientific species name). Many more compounds, related to azadirachtin, are present in the seeds as well as in the leaves and the bark of the neem tree which also show strong biological activities among various pest insects. Pure neem oil contains other insecticidal and fungicidal compounds in additional to azadirachtin, it is generally mixed at a rate of 1 ounce per gallon (7.8 ml/l) of water when used as a pesticide.
Azadirachtin is formed via an elaborate biosynthetic pathway, but is believed that the steroid tirucallol is the precursor to the neem triterpenoid secondary metabolites. Tirucallol is formed from two units of farnesyl diphosphate (FPP) to form a C30 triterpene, but then loses three methyl groups to become a C27 steroid. Tirucallol undergoes an allylic isomerization to form butyrospermol, which is then oxidized. The oxidized butyrospermol subsequently rearranges via a Wagner-Meerwein 1,2-methyl shift to form apotirucallol.
For further information, pls contact with Scientific and Industrial Research Laboratory at Delhi University.
PATENT ON NEEM
In 1995, the European Patent Office (EPO) granted a patent on an anti-fungal product derived from neem to the US Department of Agriculture and W. R. Grace and Company. The Indian government challenged the patent when it was granted, claiming that the process for which the patent had been granted had actually been in use in India for over 2,000 years. In 2000, the EPO ruled in India's favour but W. R. Grace appealed, claiming that prior art about the product had never been published in a scientific journal. On 8 March 2005, that appeal was lost and the EPO revoked the Neem patent.
Regards,
SWAMY.
